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. 2016 Sep 29;15:61. doi: 10.1186/s12943-016-0546-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Synthetic Lethality: History and Evolution. The timeline indicates the major events that took place over the last century, from the first description of synthetic lethality to the recent development of technologies for high-throughput discoveries of synthetic lethal interactions