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. 2016 Aug 2;44(17):8041–8051. doi: 10.1093/nar/gkw693

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Different models explaining the origins of tRNA. (A) tRNA may originate from the dimerization of two hairpin structures. ANTI, anticodon; ID, the discrimination region for identifying tRNA. The triangle represents the position where the intron is found in tRNA genes (73). (B) tRNA may originate from the late fusion between two RNA minihelices. A new aminoacyl tRNA synthetase (aaRS) domain links the operational RNA code to the trinucleotides of the genetic code (21). (C) tRNA may originate from the fusion of split genes of non-contiguous tRNAs (22).