Skip to main content
. 2016 Apr 18;7(18):24908–24927. doi: 10.18632/oncotarget.8795

Figure 11. Effect of DDR2 and JAK2 inhibition on ERK1/2 activation and p21CIP1 expression.

Figure 11

A. HT-1080 cells were cultured 5 days in old type I collagen 3D matrices, with or without 10 μM of AG490. Western blot analysis was performed using pERK1/2 and p21CIP1 specific antibodies. The histograms show the ratio of pERK1/2 and p21CIP1 expression relative to GAPDH. B. HT-1080 cells were cultured 5 days in adult type I collagen 3D matrices, with or without 100 nM of nilotinib. Western blot analysis was performed using pERK1/2 and p21CIP1 specific antibodies. The histograms show the ratio of pERK1/2 and p21CIP1 expression relative to GAPDH. Values represent the mean ± S.E.M. of three independent experiments (*p < 0.05, **p < 0.01).