Figure 1. Trpv5 deficiency leads to elevated serum 1,25(OH)₂D₃ and PTH levels.

Depicted is an illustration of temporal changes in serum levels of hormones involved in calcium homeostasis. Based on the measured serum calcium levels in the 10 and 52-week old animals and calcium measured of 78-week-old male mice in this and a previous study, we have depicted calcium to be constant irrespective of age and genotype (black dotted line, not representing an actual value). Both 1,25(OH)₂D₃ (triangle symbols) and PTH (round symbols) levels are elevated in 10-week-old Trpv5^−/− (open symbols) compared to Trpv5^+/+ mice (closed symbols). In fact, the serum levels for both hormones in 10-week-old TRPV5 deficient mice are similar to those in 52-week-old Trpv5^+/+ mice. The data presented are not longitudinal and hence should not be presented as a line graph but they serve solely as an illustration for temporal serum changes in mice lacking Trpv5. We emphasized this by disconnecting the lines from the actual measurements.