Table 1. Serum fibrinogen level and clinicopathologic characteristics in 1512 patients with esophageal cancer.
| Characteristic | Patients (%) | Fibrinogen | P | Fibrinogen | P | |
|---|---|---|---|---|---|---|
| Overall (n=1512) | Normal (<4.0 g/L) | High (≥4.0 g/L) | Median(mean,5th-95th) | |||
| Hp | 0.329 | 0.403 | ||||
| ESCC | 1305 (86.3) | 926 (71.0) | 379 (29.0) | 3.46(3.57, 2.25-5.41) | ||
| EA | 164(10.9) | 115(70.1) | 49(29.9) | 3.40(3.57, 2.18-5.53) | ||
| Others | 43(2.8) | 26 (60.5) | 17(39.5) | 3.67(3.89, 2.10-7.16) | ||
| Age | <0.001 | <0.001 | ||||
| ≤58 years | 782(51.7 | 590 (75.4) | 192 (24.6) | 3.38(3.47, 2.22-5.31) | ||
| >58 years | 730 (48.3) | 477(65.3) | 253 (34.6) | 3.55(3.71, 2.27-5.59) | ||
| Gender | 0.002 | 0.001 | ||||
| Females | 368(24.3) | 283 (76.9) | 85 (23.1) | 3.30(3.41, 2.25-4.91) | ||
| Males | 1144 (75.7) | 784(68.5) | 360(31.5) | 3.51(3.64, 2.22-5.60) | ||
| Smoking | 0.001 | <0.001 | ||||
| Never | 551(36.4) | 417(75.7) | 134(24.3) | 3.29(3.43, 2.15-5.11) | ||
| Ever (former + current) | 961 (63.6) | 650(67.6) | 311(32.4) | 3.53(3.67, 2.27-5.58) | ||
| Alcohol | <0.001 | <0.001 | ||||
| Never | 1062 (69.9) | 793(70.2) | 269(29.8) | 3.36(3. 47, 2.19-5.25) | ||
| Ever (former + current) | 450(30.1) | 274(60.9) | 176(39.1) | 3.71(3.84, 2.36-5.81) | ||
| Weight loss | <0.001 | <0.001 | ||||
| No | 830 (54.9) | 618 (74.5) | 212(25.5) | 3.32 (3.48, 2.18-5.40) | ||
| Yes | 682 (45.1) | 449 (65.8) | 233 (34.2) | 3.60(3.71, 2.32-5.43) | ||
| Differentiation | 0.974 | 0.909 | ||||
| G1 | 1015(67.1) | 716(70.5) | 299(29.5) | 3.46(3.59, 2.22-5.44) | ||
| G2-3 | 497(32.9) | 351(70.6) | 146(29.4) | 3.44(3.58, 2.26-5.32) | ||
| Tumor location | 0.132 | 0.089 | ||||
| Upper | 290 (19.2) | 208(71.7) | 82(28.3) | 3.45(3.57, 2.30-5.49) | ||
| Middle | 769(50.9) | 557(72.4) | 212(27.6) | 3.39(3.52, 2.19-5.34) | ||
| Lower | 297(19.6) | 193(65.0) | 104(35.0) | 3.61(3.74, 2.27-5.61) | ||
| EGJ | 156(10.3) | 109(69.9) | 47 (20.1) | 3.43(3.60, 2.21-5.62) | ||
| pT category | 0.003 | <0.001 | ||||
| T1-2 | 462(30.6) | 350(75.8) | 112(24.2) | 3.20(3.42, 2.10-5.36) | ||
| T3-4 | 1050(69.4) | 717(68.3) | 333(31.7) | 3.55(3.66, 2.29-5.50) | ||
| pN category | <0.001 | <0.001 | ||||
| N0 | 775(51.3) | 583(75.2) | 192(24.8) | 3.35(3.47, 2.20-5.17) | ||
| N1-3 | 737(48.7) | 484(65.7) | 253(34.3) | 3.55(3.70, 2.28-5.67) | ||
| Surgical procedures | 0.222 | 0.116 | ||||
| Cervicothoracoabdo-minal | 286(18.9) | 202(70.6) | 84(29.4) | 3.47(3.58, 2.33-5.28) | ||
| Ivor-Lewis | 206(13.6) | 135(65.5) | 71(34.5) | 3.43(3.56, 2.22-5.41) | ||
| Left transthoracic | 1020(67.5) | 730(71.6) | 290(29.4) | 3.55(3.72, 2.32-5.85) | ||
| No. metastatic lymph node( median, IQR) | 0(0-2) | 0(0-2) | 1(0-3) | <0.001 | - | - |
| Lymph node ratio, (median, IQR) | 0.00(0.00-0.18) | 0.00(0.00-0.15) | 0.06(0.00-0.25) | <0.001 | - | - |
Abbreviations: Hp, histopathology; ESCC, esophageal squamous cell carcinoma; EA, esophageal adenocarcinoma; EGJ, esophagogastric junction; G, grade; IQR, interquartile range
Bold values are statistically significant (P < 0.05)