Table 2. Univariate and multivariate Cox proportional hazards analysis of FOX gene expression and overall survival for patients with gastric cancer in the TCGA cohort.
Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
Factor | HR (95% CI) | P | HR (95% CI) | P |
Gender | 0.681 (0.457–1.016) | 0.060 | ||
Age | 1.020 (0.585–1.792) | 0.014 | 1.036 (1.016–1.055) | < 0.001 |
T category | 1.375 (1.094–1.727) | 0.007 | 1.326 (1.028–1.709) | 0.030 |
N stage | 1.300 (1.113–1.518) | 0.001 | 1.271 (1.077–1.500) | 0.005 |
M stage | 1.590 (1.132–2.234) | 0.007 | 1.384 (0.978–1.959) | 0.066 |
Grade | 1.313 (0.933–1.848) | 0.119 | ||
Tumor location | 0.971 (0.828–1.139) | 0.721 | ||
FOXA1 | 0.985 (0.870–1.116) | 0.815 | ||
FOXA2 | 0.979 (0.864–1.111) | 0.746 | ||
FOXA3 | 0.884 (0.773–1.013) | 0.078 | ||
FOXC1 | 0.986 (0.845–1.152) | 0.862 | ||
FOXC2 | 1.139 (0.899–1.442) | 0.282 | ||
FOXD1 | 0.955 (0.824–1.106) | 0.536 | ||
FOXD2 | 0.818 (0.640–1.044) | 0.107 | ||
FOXD3 | 1.419 (1.007–1.999) | 0.045 | 1.704 (1.212–2.397) | 0.002 |
FOXD4 | 0.564 (0.284–1.117) | 0.101 | ||
FOXF1 | 1.066 (0.923–1.239) | 0.370 | ||
FOXF2 | 0.990 (0.848–1.157) | 0.903 | ||
FOXH1 | 1.067 (0.861–1.323) | 0.552 | ||
FOXI1 | 0.694 (0.413–1.164) | 0.167 | ||
FOXJ1 | 0.971 (0.866–1.089) | 0.616 | ||
FOXJ2 | 0.980 (0.668–1.438) | 0.919 | ||
FOXJ3 | 0.897 (0.613–1.313) | 0.575 | ||
FOXK1 | 1.001 (0.751–1.336) | 0.989 | ||
FOXK2 | 0.972 (0.657–1.437) | 0.887 | ||
FOXL1 | 1.138 (0.882–1.468) | 0.320 | ||
FOXL2 | 0.998 (0.639–1.559) | 0.994 | ||
FOXM1 | 1.000 (0.835–1.197) | 0.998 | ||
FOXN2 | 0.948 (0.665–1.350) | 0.767 | ||
FOXN3 | 1.179 (0.913–.522) | 0.208 | ||
FOXO1 | 1.008 (0.753–1.349) | 0.958 | ||
FOXO3 | 1.174 (0.891–1.547) | 0.255 | ||
FOXO4 | 0.681 (0.513–0.904) | 0.008 | 0.613 (0.452–0.832) | 0.002 |
FOXP1 | 1.018 (0.751–1.380) | 0.910 | ||
FOXP2 | 1.144 (0.961–1.362) | 0.131 | ||
FOXP3 | 0.807 (0.629–1.035) | 0.092 | ||
FOXP4 | 0.938 (0.747–1.177) | 0.581 | ||
FOXQ1 | 0.919 (0.817–1.035) | 0.165 | ||
FOXS1 | 1.219 (1.008–1.474) | 0.041 | 1.180 (0.957–1.455) | 0.121 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
Bold type indicates statistical significance.