Table 3. Univariate and multivariate Cox proportional hazards analysis of FOX gene expression and overall survival for patients with gastric cancer in the validated cohort.
| Factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Gender | 0.750 (0.475–1.183) | 0.216 | ||
| Age | 1.238 (0.789–1.945) | 0.353 | ||
| T category | 1.735 (1.258–2.393) | 0.001 | 1.215 (0.801–1.843) | 0.359 |
| N stage | 1.559 (1.272–1.909) | < 0.001 | 1.373 (1.057–1.784) | 0.017 |
| Grade | 1.737 (1.096–2.751) | 0.019 | 1.705 (1.052–2.762) | 0.030 |
| Lymphovascular invasion | 1.808 (1.137–2.875) | 0.012 | 2.174 (1.348–3.506) | 0.001 |
| Perineural invasion | 1.930 (1.181–3.154) | 0.009 | 1.384 (0.837–2.290) | 0.206 |
| Tumor location | 0.170 (0.962–1.462) | 0.116 | ||
| FOXO4 | 0.445 (0.277–0.715) | 0.001 | 0.281 (0.168–0.469) | < 0.001 |
| FOXD3 | 1.927 (1.212–3.063) | 0.006 | 2.576 (1.553–4.274) | < 0.001 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
Bold type indicates statistical significance.