Table 4. Univariate and multivariate Cox proportional hazards analysis of FOX gene expression and disease free survival for patients with gastric cancer in the validated cohort.
| Factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Gender | 0.832 (0.559–1.238) | 0.365 | ||
| Age | 1.268 (0.853–1.885) | 0.240 | ||
| T category | 1.827 (1.347–2.478) | < 0.001 | 1.374 (0.956–1.975) | 0.086 |
| N stage | 1.454 (1.223–1.728) | < 0.001 | 1.306 (1.059–1.610) | 0.012 |
| Grade | 1.829 (1.220–1.743) | 0.003 | 1.608 (1.059–2.441) | 0.026 |
| Lymphovascular invasion | 1.595 (1.049–2.424) | 0.029 | 1.719 (1.121–2.638) | 0.013 |
| Perineural invasion | 2.137 (1.390–3.285) | 0.001 | 1.602 (1.029–2.493) | 0.037 |
| Tumor location | 1.116 (0.938–1.328) | 0.216 | ||
| FOXO4 | 0.628 (0.420–0.935) | 0.022 | 0.451 (0.295–0. 691) | < 0.001 |
| FOXD3 | 1.698 (1.136–2.540) | 0.010 | 1.966 (1.282–3.014) | 0.002 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
Bold type indicates statistical significance.