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. 2016 Mar 21;7(18):25604–25619. doi: 10.18632/oncotarget.8238

Figure 9. Schematic model depicts the mechanism by which Numb promotes TIF.

Figure 9

In wild type mice, the expression of Numb in TECs is induced after UUO or UIRI. Increased Numb expression leads to G2/M arrest of proximal tubular cells through stabilizing p53 protein, which in turn induces the expressions of TGF-β1 and CTGF and potentiates renal fibrosis. Tubule-specific knockout Numb reduces the number of proximal tubular cells arrested at G2/M phase (empty arrow), attenuates TIF induced by UUO or UIRI.