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| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Clinical toxicities | ||||
| Neurologic | ||||
| Neurocognitive | 1 | |||
| Neuromotor | 1 | |||
| Gastrointestinal | ||||
| Constipation | 1 | |||
| Nausea | 8 | |||
| Vomiting | 4 | |||
| Mucositis | 3 | 2 | ||
| Other | ||||
| Fatigue | 7 | 2 | 1 | |
| Laboratory toxicities | ||||
| Hematologic | ||||
| Hemoglobin | 8 | 6 | 3 | |
| Leukocytes | 8 | 8 | 3 | |
| Platelets | 5 | 2 | 1 | 4 |
| Neutrophils | 5 | 4 | 5 | 5 |
| Renal | ||||
| Creatinine | 4 | |||
| Urea nitrogen | 4 | |||
| Hepatic | ||||
| Transaminases | 9 | 5 | 3 | |
| Bilirubin | 1 | 2 | 1 | |
| Other | ||||
| Glucose | 8 | 3 | 2 | 1 |
