Table 3. Meta-regression for the potential source of heterogeneity.
Study characteristic | P-value | RDOR | 95% CI |
---|---|---|---|
Specimen type (plasma, serum or tissue) | 0.0587 | 0.56 | (0.31-1.02) |
Control sources (healthy blood, normal tissue or adjacent non-tumor tissue) | 0.9385 | 0.90 | (0.05-15.68) |
Sample size (GC<100 vs. GC≥100) | 0.1047 | 2.27 | (0.82-6.23) |
Reference gene (GAPDH vs. β-actin) | 0.5264 | 0.73 | (0.25-2.13) |
Cut-off value (value <100 vs. value ≥100) | 0.1798 | 0.71 | (0.42-1.2) |
Study quality (QUADAS score≤10 or≥11) | 0.1008 | 3.29 | (0.76-14.14) |
Abbreviations: CI: confidence interval; RDOR: relative diagnostic odds ratio; QUADAS: quality assessment for studies of diagnostic accuracy; GC: Gastric cancer; GAPDH: glyceraldehyde-phosphate dehydrogenase