Table 2. Change of the expression of the metastatic genes in the single volatile anesthetics treated group (Iso = Isoflurane, Sevo = Sevoflurane, Des = Desflurane) compared with the control group.
Table 2A: Increased in Iso group only | |||||||
---|---|---|---|---|---|---|---|
Assay | Relative change | P-value (Q-value) | |||||
Cont | Iso | Sevo | Des | Cont-Iso | Cont-Sevo | Cont-Des | |
CCL7 | 1.000±0.255 | 1.606±0.347 | 0.835±0.105 | 1.256±0.197 | 0.016(0.032) | 0.625 | 0.314 |
Table 2B: Decreased in Iso group only | |||||||
---|---|---|---|---|---|---|---|
Assay | Relative change | P-value (Q-value) | |||||
Cont | Iso | Sevo | Des | Cont-Iso | Cont-Sevo | Cont-Des | |
CHD4 | 1.000±0.133 | 0.331±0.060 | 0.741±0.105 | 1.124±0.166 | <0.001(<0.001) | 0.067 | 0.712 |
Table 2C: Increased in Des group only | |||||||
---|---|---|---|---|---|---|---|
Assay | Relative change | P-value (Q-value) | |||||
Cont | Iso | Sevo | Des | Cont-Iso | Cont-Sevo | Cont-Des | |
CDH1 | 1.000±0.504 | 0.746±0.346 | 1.443±0.235 | 4.274±1.809 | 0.785 | 0.511 | 0.003(0.008) |
TGFB1 | 1.000±0.292 | 1.187±0.292 | 1.217±0.091 | 2.788±0.827 | 0.618 | 0.451 | <0.001(<0.001) |
EWSR1 | 1.000±0.124 | 0.869±0.215 | 1.217±0.208 | 3.664±1.386 | 0.820 | 0.731 | <0.001(0.001) |
NME1 | 1.000±0.186 | 0.996±0.228 | 1.499±0.304 | 3.155±0.815 | 1.000 | 0.116 | <0.001(<0.001) |
TP53 | 1.000±0.233 | 1.063±0.325 | 1.055±0.158 | 3.347±0.861 | 0.994 | 0.981 | <0.001(0.001) |
TCF20 | 1.000±0.255 | 0.925±0.384 | 1.276±0.118 | 3.054±0.280 | 0.970 | 0.440 | <0.001(0.001) |
SMAD2 | 1.000±0.207 | 1.315±0.158 | 1.357±0.213 | 2.931±0.404 | 0.146 | 0.103 | <0.001(<0.001) |
NME4 | 1.000±0.105 | 1.015±0.025 | 0.868±0.055 | 2.208±0.436 | 0.996 | 0.425 | <0.001(<0.001) |
PLAUR | 1.000±0.363 | 1.008±0.215 | 1.390±0.128 | 2.206±0.358 | 0.991 | 0.202 | 0.003(0.008) |
SRC | 1.000±0.098 | 0.678±0.065 | 0.783±0.073 | 2.114±0.789 | 0.059 | 0.318 | 0.001(0.003) |
CD82 | 1.000±0.287 | 1.748±0.304 | 1.574±0.564 | 2.967±1.669 | 0.139 | 0.314 | 0.007(0.015) |
HTATIP2 | 1.000±0.094 | 0.827±0.236 | 1.530±0.271 | 2.731±0.661 | 0.529 | 0.090 | <0.001(0.001) |
FGFR4 | 1.000±0.225 | 1.079±0.249 | 1.169±0.181 | 2.765±0.524 | 0.963 | 0.688 | <0.001(<0.001) |
CTBP1 | 1.000±0.210 | 1.380±0.138 | 1.128±0.325 | 2.427±0.585 | 0.256 | 0.940 | 0.001(0.004) |
CTNNA1 | 1.000±0.292 | 0.685±0.184 | 0.832±0.127 | 2.413±0.560 | 0.174 | 0.770 | 0.001(0.003) |
CD44 | 1.000±0.136 | 0.886±0.234 | 1.293±0.146 | 2.395±0.144 | 0.634 | 0.183 | <0.001(<0.001) |
ITGA7 | 1.000±0.463 | 1.237±0.386 | 1.581±0.372 | 2.237±0.289 | 0.695 | 0.209 | 0.020(0.040) |
METAP2 | 1.000±0.128 | 0.853±0.256 | 1.230±0.254 | 2.153±0.483 | 0.675 | 0.652 | 0.003(0.004) |
FN1 | 1.000±0.271 | 1.099±0.077 | 0.681±0.159 | 2.042±0.353 | 0.837 | 0.093 | 0.001(0.004) |
CST7 | 1.000±0.128 | 0.935±0.102 | 1.238±0.199 | 2.000±0.209 | 0.884 | 0.151 | <0.001(<0.001) |
SET | 1.000±0.214 | 0.953±0.216 | 1.112±0.162 | 1.905±0.261 | 0.985 | 0.835 | 0.003(0.007) |
MYCL1 | 1.000±0.173 | 0.944±0.217 | 1.064±0.165 | 1.825±0.417 | 0.966 | 0.969 | 0.006(0.014) |
MMP9 | 1.000±0.174 | 0.816±0.111 | 1.133±0.191 | 1.814±0.313 | 0.390 | 0.735 | 0.002(0.005) |
FLT4 | 1.000±0.098 | 0.850±0.108 | 1.179±0.299 | 1.790±0.232 | 0.503 | 0.607 | 0.001(0.004) |
MTSS1 | 1.000±0.246 | 0.903±0.157 | 1.133±0.020 | 1.786±0.099 | 0.847 | 0.576 | 0.001(0.003) |
MMP7 | 1.000±0.133 | 1.354±0.417 | 1.352±0.199 | 1.749±0.196 | 0.054 | 0.095 | 0.002(0.005) |
CTSK | 1.000±0.160 | 0.826±0.154 | 1.199±0.151 | 1.621±0.402 | 0.476 | 0.521 | 0.017(0.035) |
CDH11 | 1.000±0.058 | 0.761±0.109 | 0.800±0.177 | 1.589±0.379 | 0.196 | 0.293 | 0.023(0.044) |
HRAS | 1.000±0.107 | 1.146±0.268 | 1.162±0.262 | 1.588±0.315 | 0.830 | 0.765 | 0.033(0.058) |
MYC | 1.000±0.127 | 0.727±0.121 | 1.164±0.200 | 1.563±0.283 | 0.066 | 0.599 | 0.012(0.025) |
ETV4 | 1.000±0.090 | 0.935±0.151 | 1.313±0.223 | 1.542±0.218 | 0.894 | 0.110 | 0.007(0.017) |
SMAD4 | 1.000±0.220 | 1.056±0.206 | 0.941±0.147 | 1.519±0.258 | 0.973 | 0.986 | 0.045(0.075) |
COL4A2 | 1.000±0.250 | 0.994±0.081 | 1.041±0.171 | 1.486±0.213 | 0.999 | 0.971 | 0.027(0.050) |
NF2 | 1.000±0.045 | 0.884±0.125 | 1.340±0.298 | 1.478±0.315 | 0.712 | 0.162 | 0.040(0.069) |
Table 2D: Decreased in Des group only | |||||||
---|---|---|---|---|---|---|---|
Assay | Relative change | P-value (Q-value) | |||||
Cont | Iso | Sevo | Des | Cont-Iso | Cont-Sevo | Cont-Des | |
EPHB2 | 1.000±0.224 | 0.942±0.182 | 0.656±0.130 | 0.586±0.122 | 0.980 | 0.061 | 0.016(0.032) |
Table 2E: Decreased in Iso group and increased in Sevo and Des group | |||||||
---|---|---|---|---|---|---|---|
Assay | Relative change | P-value (Q-value) | |||||
Cont | Iso | Sevo | Des | Cont-Iso | Cont-Sevo | Cont-Des | |
MTA1 | 1.000±0.240 | 0.616±0.092 | 1.775±0.259 | 2.823±0.623 | 0.030(0.054) | 0.007(0.016) | <0.001(<0.001) |
Table 2F: Increased in Sevo and Des group | |||||||
---|---|---|---|---|---|---|---|
Assay | Relative change | P-value (Q-value) | |||||
Cont | Iso | Sevo | Des | Cont-Iso | Cont-Sevo | Cont-Des | |
CXCR2 | 1.000±0.185 | 1.792±0.059 | 2.918±0.235 | 4.902±1.073 | 0.139 | <0.001(<0.001) | <0.001(<0.001) |
PTEN | 1.000±0.198 | 1.118±0.309 | 3.357±0.615 | 5.566±1.147 | 0.922 | <0.001(<0.001) | <0.001(<0.001) |
HGF | 1.000±0.156 | 1.446±0.235 | 2.390±0.483 | 5.211±1.155 | 0.094 | <0.001(0.001) | <0.001(<0.001) |
IGF1 | 1.000±0.262 | 0.813±0.237 | 2.139±0.329 | 4.387±0.693 | 0.566 | 0.002(0.005) | <0.001(<0.001) |
RORB | 1.000±0.230 | 1.465±0.167 | 1.978±0.348 | 4.268±0.898 | 0.052 | 0.001(0.004) | <0.001(<0.001) |
TNFSF10 | 1.000±0.282 | 0.643±0.081 | 2.259±0.499 | 3.961±0.548 | 0.052 | <0.001(0.002) | <0.001(<0.001) |
CTSL1 | 1.000±0.142 | 0.959±0.240 | 1.684±0.451 | 3.856±0.603 | 0.982 | 0.031(0.055) | <0.001(<0.001) |
MGAT5 | 1.000±0.024 | 1.221±0.250 | 3.270±0.731 | 3.813±0.464 | 0.461 | <0.001(<0.001) | <0.001(<0.001) |
RPSA | 1.000±0.159 | 0.744±0.187 | 1.756±0.138 | 3.664±0.637 | 0.132 | 0.004(0.010) | <0.001(<0.001) |
FAT1 | 1.000±0.133 | 1.159±0.204 | 2.233±0.619 | 3.150±0.958 | 0.839 | 0.003(0.008) | <0.001(0.001) |
TIMP2 | 1.000±0.335 | 1.276±0.099 | 1.517±0.109 | 3.130±0.447 | 0.212 | 0.025(0.046) | <0.001(<0.001) |
MMP13 | 1.000±0.070 | 0.854±0.068 | 1.539±0.167 | 2.986±0.406 | 0.197 | <0.001 | <0.001(<0.001) |
SYK | 1.000±0.025 | 0.973±0.128 | 1.593±0.246 | 2.943±0.417 | 0.982 | 0.002(0.005) | <0.001(<0.001) |
KRAS | 1.000±0.259 | 1.210±0.211 | 1.954±0.263 | 2.858±0.367 | 0.419 | 0.001(0.003) | <0.001(<0.001) |
VEGFA | 1.000±0.214 | 1.063±0.347 | 1.612±0.281 | 2.406±0.619 | 0.952 | 0.025(0.046) | <0.001(0.001) |
IL1B | 1.000±0.215 | 1.300±0.132 | 2.313±0.510 | 2.754±0.623 | 0.290 | 0.001(0.002) | <0.001(0.001) |
NR4A3 | 1.000±0.096 | 1.008±0.189 | 1.400±0.189 | 2.438±0.434 | 1.000 | 0.048(0.079) | <0.001(<0.001) |
MMP11 | 1.000±0.481 | 1.170±0.643 | 1.284±0.141 | 1.261±0.229 | 0.184 | 0.018(0.021) | 0.015(0.019) |
KISS1R | 1.000±0.043 | 1.205±0.250 | 1.555±0.211 | 2.158±0.331 | 0.413 | 0.007(0.017) | <0.001(<0.001) |
DENR | 1.000±0.239 | 1.461±0.327 | 2.345±0.412 | 2.089±0.499 | 0.121 | 0.001(0.002) | 0.002(0.006) |
MET | 1.000±0.226 | 1.207±0.085 | 1.597±0.281 | 1.961±0.422 | 0.465 | 0.022(0.042) | 0.002(0.005) |
CXCL12 | 1.000±0.109 | 1.088±0.228 | 1.641±0.276 | 1.826±0.304 | 0.931 | 0.008(0.017) | 0.002(0.005) |
PNN | 1.000±0.087 | 0.986±0.128 | 1.378±0.208 | 1.728±0.217 | 0.997 | 0.022(0.042) | <0.001(0.001) |