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A. Spindle shaped cells highly express L1CAM, while L1CAM expression on cobble shaped cells is very low. B. Spindle and cobble cells form spheroids equally well and invade when embedded in a collagen matrix (C. and D.). Note that the invasion of the non-L1CAM expressing cobble shaped cells (C) is hardly affected by L1CAM neutralising antibodies, while spindle cell invasion can be strongly inhibited by the L1CAM neutralising antibodies (D)
