Table 2. Effect of APE1 genetic variants described in this study on various molecular and cellular parameters.
| APE1geneticvariant | Predicted effects | Interactome network | Biological outcome | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Loss of AP-endo activity | Loss of structure stability | Destabilizing overalleffects | BERproteins | Loss of AP-endo activity | Cellcycleperturbation | Cellviabilityduringstressconditions | Autophagyinduction | DDRactivation | |
| L104R | + | + | + | ↓ | + | + | + | + | + |
| D148E | − | − | − | − | − | N.D. | N.D. | + | + |
| R237C | ++ | + | + | ↓ | ++ | − | + | ++ | ++ |
| D283G | +++ | + | + | ↓ | +++ | + | + | +++ | +++ |
N.D., not determined.