Table 3. Association of miRNA genotypes with OS, DSS, and DFS of SCCNOP patients stratified by smoking status.
| Genotypes | OS | DSS | DFS | |||
|---|---|---|---|---|---|---|
| Overall death/Total | HRa (95% CI) | Death, owing to disease/Total | HRa (95% CI) | Recurrence/Total | HRa (95% CI) | |
| Ever smoker patients (N = 743) | ||||||
| hsa-mir-146a rs2910164 | ||||||
| CG + CCb | 116/346 | 1.0 | 64/343 | 1.0 | 82/346 | 1.0 |
| GG | 126/397 | 0.9 (0.7–1.1) | 55/400 | 0.7 (0.5–1.1) | 83/397 | 0.8 (0.6–1.1) |
| hsa-mir-196a2 rs11614913 | ||||||
| CT + TTb | 136/416 | 1.0 | 69/413 | 1.0 | 94/416 | 1.0 |
| CC | 106/327 | 1.0 (0.8–1.3) | 50/330 | 0.9 (0.7–1.3) | 71/327 | 0.9 (0.7–1.2) |
| hsa-mir-149 rs2292832 | ||||||
| CT + TTb | 124/374 | 1.0 | 65/370 | 1.0 | 86/374 | 1.0 |
| CC | 118/369 | 0.7 (0.6–0.9) | 54/373 | 0.7 (0.5–0.9) | 79/369 | 0.7 (0.6–0.9) |
| hsa-mir-499 rs3746444 | ||||||
| CT + CCb | 112/328 | 1.0 | 61/324 | 1.0 | 85/328 | 1.0 |
| TT | 130/415 | 0.7 (0.5–0.9) | 58/419 | 0.5 (0.4–0.8) | 80/415 | 0.5 (0.4–0.9) |
| Never smoker patients (N = 253) | ||||||
| hsa-mir-146a rs2910164 | ||||||
| CG + CCb | 21/107 | 1.0 | 13/107 | 1.0 | 23/107 | 1.0 |
| GG | 31/146 | 1.3 (0.7–2.2) | 20/146 | 1.4 (0.7–2.8) | 36/146 | 1.4 (0.8–2.5) |
| hsa-mir-196a2 rs11614913 | ||||||
| CT + TTb | 17/118 | 1.0 | 11/118 | 1.0 | 20/118 | 1.0 |
| CC | 35/135 | 2.0 (1.1–3.8) | 22/135 | 2.2 (1.0–4.6) | 39/135 | 2.0 (1.1–3.5) |
| hsa-mir-149 rs2292832 | ||||||
| CT + TTb | 29/136 | 1.0 | 18/135 | 1.0 | 31/136 | 1.0 |
| CC | 23/117 | 0.9 (0.4–1.3) | 15/118 | 0.8 (0.5–1.4) | 28/117 | 1.0 (0.5–1.7) |
| hsa-mir-499 rs3746444 | ||||||
| CT + CCb | 25/124 | 1.0 | 16/123 | 1.0 | 30/124 | 1.0 |
| TT | 27/129 | 0.9 (0.3–1.4) | 17/130 | 0.9 (0.6–1.3) | 29/129 | 0.8 (0.6–1.4) |
a
Adjusted for age, sex, ethnicity, alcohol use status, stage, comorbidity, and treatment.
b
Reference group.