Table 4. Association of miRNA genotypes with OS, DSS, and DFS of SCCNOP patients stratified by treatment.
| Genotypes | OS | DSS | DFS | |||
|---|---|---|---|---|---|---|
| Overall death/Total | HRa (95% CI) | Death, owing to disease/Total | HRa (95% CI) | Recurrence/Total | HRa (95% CI) | |
| Patients treated with surgery only (N = 333) | ||||||
| hsa-mir-146a rs2910164 | ||||||
| CG + CCb | 34/147 | 1.0 | 10/147 | 1.0 | 19/147 | 1.0 |
| GG | 25/186 | 0.7 (0.4–1.2) | 10/186 | 0.8 (0.3–2.0) | 25/186 | 1.1 (0.6–2.1) |
| hsa-mir-196a2 rs11614913 | ||||||
| CT + TTb | 29/165 | 1.0 | 10/165 | 1.0 | 20/165 | 1.0 |
| CC | 30/168 | 1.1 (0.7–1.9) | 10/168 | 1.1 (0.5–2.8) | 24/168 | 1.3 (0.7–2.4) |
| hsa-mir-149 rs2292832 | ||||||
| CT + TTb | 31/173 | 1.0 | 11/173 | 1.0 | 23/173 | 1.0 |
| CC | 28/160 | 0.6 (0.4–1.1) | 9/160 | 0.4 (0.1–1.1) | 21/160 | 0.7 (0.4–1.2) |
| hsa-mir-499 rs3746444 | ||||||
| CT + CC | 29/154 | 1.0 | 12/154 | 1.0 | 21/154 | 1.0 |
| TT | 30/179 | 0.6 (0.3–1.1) | 8/179 | 0.5 (0.2–1.2) | 23/179 | 0.8 (0.4–1.3) |
| Patients treated with chemoradiation (N = 663) | ||||||
| hsa-mir-146a rs2910164 | ||||||
| CG + CCb | 103/306 | 1.0 | 67/303 | 1.0 | 86/306 | 1.0 |
| GG | 132/357 | 1.0 (0.8–1.3) | 65/360 | 0.8 (0.5–1.1) | 94/357 | 0.9 (0.7–1.2) |
| hsa-mir-196a2 rs11614913 | ||||||
| CT + TTb | 124/369 | 1.0 | 70/366 | 1.0 | 94/369 | 1.0 |
| CC | 111/294 | 1.1 (0.9–1.4) | 62/297 | 1.0 (0.8–1.4) | 86/294 | 1.0 (0.8–1.3) |
| hsa-mir-149 rs2292832 | ||||||
| CT + TTb | 136/337 | 1.0 | 72/332 | 1.0 | 102/337 | 1.0 |
| CC | 99/326 | 0.6 (0.3–0.8) | 60/331 | 0.7 (0.5–1.0) | 78/326 | 0.6 (0.3–0.9) |
| hsa-mir-499 rs3746444 | ||||||
| CT + CCb | 133/298 | 1.0 | 68/293 | 1.0 | 94/298 | 1.0 |
| TT | 102/365 | 0.6 (0.4–0.9) | 64/370 | 0.5 (0.4–0.8) | 86/365 | 0.5 (0.3–0.7) |
a
Adjusted for age, sex, ethnicity, smoking status, alcohol use status, stage, and comorbidity.
b
Reference group.