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. 2016 Mar 28;7(18):26465–26479. doi: 10.18632/oncotarget.8417

Figure 3. Effect of estrogens on RET-pathway gene expression.

Figure 3

mRNA quantification of RET, GFRa1, NRTN and ARTN after 6 hours of 17β-estradiol (B-17-estr) treatment in MCF7 A. and T47D B. RET expression as assessed after 6 hours C. and 48 hours D. of B-17-estr treatment in both the MCF7 and T47D cell lines. E. RET9 and RET51 mRNA fold induction after 6 hours of B-17-estr administration in MCF7 and T47D. F. Levels of RET and estrogen receptor (ESR1) mRNAs induced by either estrogens depleted DMEM media (MCF7 and T47D) or standard DMEM (MCF7r and T47Dr). Values are the mean ±SD of at least two independent experiments performed in triplicate; asterisks (*) indicate statistically significant differences (*p<0.05; **p<0.01).