Table 2. Univariate and multivariate analyses of overall survival in esophageal carcinoma (density of CTLA-4⁺ TIMCs).

Variable	Univariate analyses			Multivariate analyses
	HR	95% CI	P-value	HR	95% CI	P-value
Density of CTLA-4 +TIMCs	1.744	1.099–2.767	0.018a	1.472	0.913–2.374	0.113
Histological grade	1.701	1.229–2.356	0.001a	1.460	1.025–2.708	0.036a
Age	1.101	0.700–1.734	0.677	1.101	0.672–1.804	0.702
Sex				1.184	0.625–2.244	0.605
Length	1.179	0.741–1.877	0.488	1.136	0.666–1.938	0.639
Location	1.153	0.774–1.718	0.483	1.185	0.802–1.751	0.395
T	2.368	1.323–4.237	0.004a	1.845	0.853–3.990	0.119
N	2.811	1.766–4.474	<0.001a	1.770	0.729–4.292	0.207
M	2.312	0.933–5.731	0.07	1.560	0.485–5.016	0.456
TNM	3.368	2.130–5.324	<0.001a	1.340	0.503–3.574	0.558

Abbreviations: HR, hazard ratio; CI, confidence interval; TIMCs: tumour-infiltrating mononuclear cells; TNM, tumor, node, metastasis.

^aP < 0.05.