Table 3. Effects of galectin-1 and P38 inhibitor on the IC50 of adriamycin and imatinib in K562, K562/Gal-1, and K562/ADM cells.
IC50 | K562/pc | K562/Gal-1 | K562/ADM | |||||
---|---|---|---|---|---|---|---|---|
– | – | DMSO | SB202190 | sc siRNA | Gal-1 siRNA | DMSO | SB202190 | |
ADM(μg/ml) | 0.485±0.03 | 1.676±0.145 | 1.636±0.141 | 1.29±0.125 | 25.56±0.41 | 14.76±0.45 | 26.51±0.44 | 16.24±0.48 |
imatinib(μM) | 0.23±0.035 | 0.84±0.087 | 0.8±0.083 | 0.4±0.037 | 2.5±0.214 | 1.1±0.12 | 2.27±0.211 | 0.5±0.46 |