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. 2016 Mar 31;7(18):26765–26779. doi: 10.18632/oncotarget.8503

Figure 1. LMP1 induces malignant phenotype of NPC cells.

Figure 1

A. morphologic changes after induced expression of LMP1 with doxycycline in CNE1 and HNE2 cells harboring LMP1 (LMP1) or empty vector (Ctrl), respectively. Scale bars, 50 um. B. western blot analysis showed expression of epithelial markers E-cadherin, Involucrin, CK8, and mesenchymal markers β-catenin, vimentin and CK13 after induced expression of LMP1 with doxycycline in CNE1 and HNE2 cells harboring LMP1 or empty vector, respectively. C. colony formation assays showed that induced expression of LMP1 enhanced the cell growth of CNE1 and HNE2 cells. D. & E. & F. the wounding healing assays, transwell migration and invasion assays showed that induced expression of LMP1 enhanced the migration and invasion ability of CNE1 and HNE2 cells. G. mouse xenograft assay indicated that induced expression of LMP1 enhanced cell growth in vivo. **p < 0.01, ***p < 0.001, two-tailed Student's t-test.