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. 2016 Mar 31;7(18):26765–26779. doi: 10.18632/oncotarget.8503

Figure 4. ATOH8 inhibition enhances malignant phenotype of NPC.

Figure 4

A. western blot analysis with indicated antibodies in CNE1 cells harboring ATOH8 interfering RNA (shATOH8-1, shATOH8-2, shATOH8-3), or negative control RNA (shCtrl) after induced with doxycycline. B. MTT assays showed that ATOH8 inhibition enhanced cell proliferation of CNE1 cells. C. Colony formation assays showed that ATOH8 inhibition enhanced the cell growth of CNE1 cells. D. & E. & F. the wounding healing assays, transwell migration and invasion assays showed that ATOH8 inhibition enhanced the migration and invasion ability of CNE1 cells. G. mouse xenograft assays indicated that ATOH8 inhibition enhanced CNE1 cell growth in vivo. **p < 0.01, ***p < 0.001, two-tailed Student's t-test.