Table 3. Univariate and multivariate analyses to predict overall survival.
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Gender | ||||
| male | 0.965 (0.497-1.872) | 0.916 | / | / |
| female | ||||
| Age (Years) | 1.01 (0.976-1.045) | 0.563 | / | / |
| MSKCC score | ||||
| Low risk | 2.25 (1.260-4.018) | 0.006 | 2.73 (1.425-5.229) | 0.002 |
| Intermediate risk | ||||
| High risk | ||||
| ECOG | ||||
| 0 | 2.079 (1.278-3.384) | 0.003 | 2.279 (1.397-3.717) | 0.001 |
| 1 | ||||
| 2 | ||||
| 3 | ||||
| KPS | ||||
| >70 | 15.042(3.73-60.60) | 0 | ||
| ≤70 | ||||
| DFI | ||||
| ≥1y | 1.406 (0.784-2.522) | 0.253 | / | / |
| <1y | ||||
| Hemoglobin | ||||
| High | 1.001 (0.481-2.084) | 0.997 | / | / |
| Low | ||||
| Corrected calcium | ||||
| ≤10 mg/dL | 0.049 | 0.868 | / | / |
| >10 mg/dL | ||||
| LDH | ||||
| High | 4.208 (1.552-11.409) | 0.005 | / | / |
| Low | ||||
| Metastasis other than bone | ||||
| Lung | 2.56 (1.387-4.724) | 0.003 | 1.585 (0.707-3.552) | 0.264 |
| Liver | 2.092 (0.852-5.135) | 0.107 | / | / |
| Lymph nodes | 2.094 (1.050-4.173) | 0.036 | 4.463 (2.023-9.844) | 0 |
| Brain | 1.451 (0.346-6.074) | 0.611 | / | / |
| Others | 1.481 (0.581-3.778) | 0.411 | / | / |
| Number of SREs | 1.273 (0.670-2.421) | 0.461 | ||
| Metastatic state | ||||
| oligometastasis | 3.201 (1.601-6.402) | 0.001 | 3.468 (1.316-9.141) | 0.012 |
| non-oligometastasis | ||||
Abbreviations: MSKCC=Memorial Sloan Kettering Cancer Center; ECOG=Eastern Cooperative Oncology Group; KPS= Karnofsky Performance Status;DFI=disease-free interval; LDH=lactate dehydrogenase; HR=hazards ratio; CI=Confidence interval; SREs=Skeletal related events