Fig. 4.

Transgenic mouse bioassay of CWD in Tg338 and TgElk. Shown are the outcomes for the first intracerebral inoculation of mice with CWD derived from white-tailed deer (WTD804). Closed circles, mice culled at the onset of clinical disease and PrP^res detected in the brain; open circles, preclinical mice (culled due to intercurrent health issues, PrP^res detected in the brain); open squares, mice with no detectable PrP^res in the brain at the time of cull. Censored data are included. Tg338 inoculated with white-tailed deer brain homogenate harbouring CWD prions did not develop clinical disease and had no detectable PrP^res in the brain, whereas nearly all TgElk mice similarly inoculated were culled at onset of clinical disease and all had detectable PrP^res in the brain.