Table 1.
Clinical characteristics of study populations from the Moroccan family-based and case–control studies
| Characteristic | Family-based
|
Case–control
|
||
|---|---|---|---|---|
| Founders | Offspring | Cases | Controlsa | |
| N | 252 | 306 | 317 | 650 |
| N by status (affected; unaffected) | 42; 210 | 239; 67 | 317; 0 | 0; 650 |
| Age in years: mean (SD, range) by status | ||||
| Affectedb | 41.4 (12.9, 16–70) | 21.3 (7.8, 1–48) | 29.3 (10.8, 1–69) | – |
| Unaffected | 51.1 (9.4, 26–73) | 25.9 (9.5, 5–50) | – | 31.5 (9.3, 16–68) |
| % Males by status | ||||
| Affected | 55 | 56.2 | 71.9 | – |
| Unaffected | 38.4 | 38.8 | – | 57.9 |
a
Controls were recruited from among healthy blood donors. Although we cannot exclude the possibility that some of these controls may develop PTB later in life (in any case no more than 5%, the expected proportion of infected individuals who develop PTB after infection by M. tuberculosis), the level of misclassification should be quasi-negligible (<5%) as the control population is older than the cases and do not have any history of TB
b
Age at PTB onset for affected individual