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. Author manuscript; available in PMC: 2016 Sep 29.
Published in final edited form as: J Invest Dermatol. 2016 Sep;136(9):e87–e93. doi: 10.1016/j.jid.2016.06.007

Figure 5. TALEN-mediated genome editing for correction of RDEB.

Figure 5

(a) RDEB patient suffering from chronic blistering. Panel a reprinted with permission from Elsevier (Petrof et al., 2015). (b) Confocal image of the epidermal-dermal junction in noncorrected RDEB cells, in which collagen VIIA is not detected. (c) Confocal image of the epidermal-dermal junction in gene-corrected RDEB cells, in which collagen VIIA is detected in the red channel. Panels b and c reprinted with permission from Macmillan Publishers Ltd: Molecular Therapy (Osborn et al., 2013). RDEB, recessive dystrophic epidermolysis bullosa; TALEN, transcription activator-like effector nuclease.

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