Table 1.

Grading scales used to measure clinical activity, glucosamine scan uptake, bone scan uptake, MRI and X-ray activity

Grading Scores	Grades
Clinical	0 Nil disease; 0 joints affected*; examination normal
	1 Mild disease; <10 small joints affected
	2 Moderate disease; 10–20 small joints or 1–3 large joints affected
	3 Severe disease; >20 small joints or ≥4 large joints affected
Glucosamine Scan	0 Nil uptake
	1 Minor uptake
	2 Mild uptake
	3 Moderate uptake
	4 Severe uptake
	5 Marked uptake
Bone Scan	0 Nil uptake
	1 Minor uptake
	2 Mild uptake
	3 Moderate uptake
	4 Severe uptake
	5 Marked uptake
MRI (Joint Specific)	0 Normal
	1 Mild synovitis, without marrow oedema on T1 or STIR/T2FS
	2 Advanced synovitis, with marrow oedema on T1 or STIR/T2FS
	3 Erosions, without chondral loss
	4 Erosions, with chondral loss
	5 Ankylosis, synovitis and chondral loss, with or without erosions
Sacro-iliac joints (X-ray)	0 Normal
	1 Some blurring of joint margins
	2 Minimal sclerosis, with some erosions
	3 Definite sclerosis on both sides of joints; severe erosions with widening of joint space, with or without ankylosis
	4 Complete ankylosis

MRI: magnetic resonance imaging; STIR: short tau inversion recovery imaging; FS-T2: fat-suppressed T2-weighted images

^*Joints were considered as affected if they were both tender and swollen.