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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Inorganica Chim Acta. 2016 Apr 23;452:12–24. doi: 10.1016/j.ica.2016.04.017

Figure 4.

Figure 4

A scheme of conserved sequences of the 8-17 DNAzyme revealed by mutational analysis. Mutations of the bases shown in black to any other natural base resulted in >100-fold decrease in activity. Removal of the functional groups highlighted in gray circles caused >100-fold decrease in activity. Residues shown in gray are those whose replacement by modified bases caused >10-fold decrease in activity. Residues shown in white were more tolerant to mutagenesis. Figure adapted with permission from ref 86.