. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: Inorganica Chim Acta. 2016 Apr 23;452:12–24. doi: 10.1016/j.ica.2016.04.017

Table 1.

Examples of different reactions catalyzed by DNAzymes in the presence of different metal ions

Reaction type	Metal cofactor	Refs
RNA cleavage	Pb²⁺, Mg²⁺, Zn²⁺, Ca²⁺, Mn²⁺, Ni²⁺, Mg²⁺, UO²⁺, Co²⁺, Na⁺, trivalent lanthanides	^1,8–24
RNA phosphorothioate cleavage	Cd²⁺	²⁵
DNA cleavage (oxidative)	Cu²⁺	^26–28
DNA cleavage (hydrolytic)	Zn²⁺, Mn²⁺, Ce³⁺/Eu³⁺/Yb³⁺	^29–32
Phosphoramidate bond cleavage	Mg²⁺	³³
DNA ligation	Cu²⁺, Zn²⁺, Mn²⁺	^34,35
RNA ligation (2′–5′)	Mg²⁺	³⁶
RNA ligation (3′–5′)	Zn²⁺, Mg²⁺	^37,38
RNA ligation (branch formation)	Mn²⁺, Mg²⁺	^39–42
RNA ligation (lariat formation)	Mn²⁺	³⁹
Nucleopeptide linkage formation	Mn²⁺, Mg²⁺	^43–45
DNA phosphorylation	Mn²⁺, Cu²⁺	⁴⁶
DNA capping	Mg²⁺, Cu²⁺	^47,48
DNA depurination	Ca²⁺	⁴⁹
Diels-Alder reaction	Ca²⁺	⁵⁰
Porphyrin metallation	Cu²⁺, Zn²⁺	^51,52
Amide hydrolysis	Zn²⁺, Mn²⁺, or Mg²⁺	⁵³
Peptide phosphatase activity	Zn²⁺	⁵⁴
Tyrosine kinase activity	Zn²⁺, Mn²⁺, Mg²⁺	^55,56
Friedel-Crafts reaction	Cu²⁺	⁵⁷