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. Author manuscript; available in PMC: 2016 Sep 29.
Published in final edited form as: Am J Surg Pathol. 2014 Jul;38(7):925–933. doi: 10.1097/PAS.0000000000000187

Figure 3.

Figure 3

Partly pigmented compound Spitz nevus with a TPM3-ALK fusion from the thigh of an 11-year-old girl (case 3). A, Wedge-shaped silhouette of a compound spindle cell melanocytic proliferation with epidermal hyperplasia (hematoxylin and eosin-stained section). B, The junctional component shows features of a pigmented spindle cell nevus. C, Deeper section of the lesion, which was adjacent to the section used for immunohistochemistry. The junctional melanocytic proliferation shows a predominant nested pattern and is pigmented. The intradermal melanocytes are amelanotic and display a plexiform growth pattern. D, The tumor cells are positive for ALK in immunohistochemistry. E, FISH confirms the ALK rearrangement.