Table.

Clinical and pathologic features of patients and their tumors

Patient	Age/ Gender	Site	Dx	Breslow Thickness	Clark Level	TMR	Polypoid	Pigmentation	Ulcer	Plexiform	Inflammation	IHC- ALK	FISH- ALK	Fusion Partner	Cytogenetics
1	5/M	Chin	CSN	2.5	IV	0	Yes	+	+	+	−	+	+	TPM3	− (FISH)
2	25/M	Lt Low Leg	CSN	4	III	0	Yes	−	−	+	−	+	+	TPM3	− (FISH)
3	11/F	Rt Ant Thigh	CSN	2.5	IV	0	No	+	−	+	Mild	+	+	TPM3	− (FISH)
4	35/M	Lt Ear	AST	2	IV	0	Yes	−	−	+	Mild	+	+	TPM3	− (CGH)
5	14/M	Rt Buttock	AST	3.7	IV	3	Yes	−	−	+	Mild	+	+	TPM3	ND
6	2/M	Lt Arm	AST	4.5	IV	3	Yes	−	−	+	Mild	+	+	TPM3	ND
7	16/F	Lt Buttock	AST	2	IV	1	Yes	−	−	+	Mild	+	+	TPM3	ND
8	14/F	NA	CSN	3.5	IV	1	Yes	−	−	+	Mild	+	+	TPM3	ND
9	17/F	Lt Ankle	AST	6	IV	4	Yes	−	−	+	−	+	+	TMP3	ND
10	23/F	Rt Toe	AST	2.5	V	1	No	−	−	+	−	+	+	TPM3	− (FISH)
11	19/F	Lt Abdomen	CSN	1.8	IV	0	Yes	−	−	+	−	+	+	TPM3	− (FISH)
12	14/M	Rt Ear	AST	3	IV	1	Yes	−	+	+	Mild	+	+	DCTN1	ND
13	9/F	Rt Lat.Thigh	AST	4.4	V	2	Yes	−	−	+	Mild	+	+	DCTN1	− (CGH)
14	28/F	Rt Back	AST	2.5	IV	0	No	−	−	(+)	Mild	+	+	DCTN1	ND
15	9/M	NA	AST	1.8	IV	1	Yes	−	−	+	Moderate	+	+	DCTN1	ND
16	19/M	Lt Arm	AST	1.5	IV	0	Yes	−	−	(+)	Mild	+	+	DCTN1	ND
17	35/M	Lt Leg	AST	1.1	IV	0	No	−	−	+	Mild	+	+	DCTN1	− (FISH)

Abbreviations:

M = male; F = female; Dx = diagnosis; CSN = compound Spitz nevus; AST = atypical Spitz tumor; NA = information not available; ND = not done; − = negative or absent; + = positive or present; (+) only focally present; rt = right; lt = left; TPM3 = tropomyosin 3; DCTN1 = dynactin 1; FISH – fluorescence in situ hybridization; CGH = comparative genomic hybridization