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Aptamer sequences and secondary structures. (A) aptamers with simple stem-loop structures, (B) aptamers with one internal bulge-loop, and (C) aptamers with two internal bulge-loops. The sequences shown have been optimized for GTP binding. Regions that showed W−C covariation are drawn as lines of plain text. The 5‘ end of each aptamer is at the top-left end of the structure. The information content of each position within the loops is color-coded as indicated.
