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. 2016 Sep 29;11(9):e0163568. doi: 10.1371/journal.pone.0163568

Fig 5. In vitro insulin secretion of NHA2 WT and KO islets.

Fig 5

A) Basal (2 mM) and glucose (20 mM) induced insulin secretion of islets isolated from 2 or 5 months old mice fed a normal chow (NFD) or from 5 months old mice fed a high fat diet (HFD) for 12 weeks; n = 300 islets per genotype and condition. Data are mean values ± SEM, (* p<0.05, WT vs KO; NS = not significant, WT vs KO; # p<0.05, WT vs WT or KO vs KO. B) NHA2 mRNA expression in islets of 2, 3.5, 5 and 12 months old mice fed a normal chow (NFD) or from 5 months old mice fed a high fat diet (HFD) for 12 weeks; n = 300–500 islets of 3–5 mice/group. Data are mean values ± SEM, (* p<0.05, vs indicated condition; # p<0.05, vs all other conditions).