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. 2016 Aug 30;7(9):55. doi: 10.3390/genes7090055

Figure 2.

Figure 2

Regulation of the Hippo signaling pathway in mammalian cells. The Hippo pathway is regulated by several upstream regulators: (1) proteins involved in cell polarity; (2) WNT and GPCR signaling; (3) components of the adherens and tight junctions. Pointed arrowheads represent activating interactions, whereas blunt arrowheads represent interactions that are inhibitory.