Table 3. RT-QuIC titration of ScBH treated with BrioHOCl with increasing available Cl.
| Experiment 1 | Experiment 2 | ||||
|---|---|---|---|---|---|
| Active Cl | Log10SD50/mg brain | pH | Active Cl | Log10SD50/mg brain | pH |
| saline | >7.70 | 7.4 | saline | >7.70 | 7.4 |
| 15.5 ppm Cl | >7.20 | 6.3 | 16 ppm Cl | >7.20 | 3.9 |
| 38.8 ppm Cl | >7.20 | 5.9 | 40 ppm Cl | >7.20 | 3.9 |
| 77.5 ppm Cl | >7.20 | 4.3 | 80 ppm Cl | >6.95 | 3.9 |
| 155 ppm Cl | 5.45 | 3.9 | 160 ppm Cl | 5.20 | 3.9 |
| 232 ppm Cl | 4.20 | 3.9 | 240 ppm Cl | 4.70 | 3.9 |
| 310 ppm Cl | <3.45 | 3.8 | 320 ppm Cl | <4.20 | 3.9 |
a log10SD50/mg brain calculated from end-point dilution RT-QuIC experiments conducted at 42°C with the reaction well data collected at a 50 hour time point.