Table 1. Baseline characteristics of patients.
| parameter | All patientsn = 195 | Low syndecan-4 n = 126 | High syndecan-4 n = 69 | p |
|---|---|---|---|---|
| Age (years) | 69.5 ± 7.95 | 66.7 ± 7.08 | 74.6 ± 6.35 | < 0.001 |
| HD vintage (months) | 46.2 ± 25.74 | 45.7 ± 24.78 | 47.1 ± 23.64 | 0.672 |
| MI (%) | 25.6 | 21.0 | 34.3 | < 0.001 |
| Diabetes mellitus (%) | 57.1 | 54.8 | 61.2 | 0.012 |
| Hypertension (%) | 85.3 | 86.3 | 83.6 | 0.341 |
| Smoking | 13.1 | 13.7 | 11.9 | 0.493 |
| Beta-blockers (%) | 86.4 | 83.1 | 92.5 | 0.001 |
| ACE/ARB (%) | 75.4 | 77.4 | 71.6 | 0.285 |
| Statins (%) | 59.2 | 60.5 | 56.7 | 0.393 |
| E/e`(n) | 14.82 ± 5.28 | 13.96± 5.13 | 16.39 ± 4.77 | 0.011 |
| LVMI (g/m2) | 144.2 ± 42.74 | 131.2 ± 41.83 | 169.3 ± 31.68 | < 0.001 |
| EF (%) | 56.83 ± 6.33 | 54.72 ± 6.01 | 60.72 ± 5.76 | 0.001 |
| LAVI (ml/m2) | 36.75 ± 8.24 | 35.24 ±7.24 | 38.34±7.75 | 0.012 |
| Hemoglobin (g/dL) | 11.07 ± 1.21 | 11.03 ± 0.98 | 11.21 ±1.22 | 0.590 |
| Total cholesterol (mg/dL) | 187.4 ± 37.35 | 188.1 ± 37.11 | 186.0 ± 35.87 | 0.674 |
| LDL cholesterol (mg/dL) | 116.9 ± 31.03 | 116.1 ± 30.13 | 118.3 ± 28.02 | 0.632 |
| HDL cholesterol (mg/dL) | 43.12 ± 18.11 | 43.4 ± 17.86 | 42.67 ± 14.45 | 0.711 |
| Triglycerides (mg/dL) | 172.1 ± 61.24 | 170.2 ± 59.54 | 175.7 ± 54.9 | 0.314 |
| PTH, range (pg/mL) | 394 (0.0–1212) | 375 (0.0–924) | 468 (0.0–1212) | 0.215 |
| Albumin (g/dL) | 3.68 ± 0.37 | 3.69 ± 0.36 | 3.61 ± 0.32 | 0.775 |
| CRP, range (mg/dL) | 7.98 (0.22–112.1) | 5.34 (0.22–67.4) | 9.72 (1.18–112.1) | 0.132 |
| Troponin T, range (μg/L) | 0.051 (0.00–0.775) | 0.034(0.00–0.379) | 0.098(0.032–0.775) | 0.021 |
| NT-proBNP (fmol/ml) | 301.3 ± 135.4 | 276.7± 125.9 | 346.9 ± 101.8 | 0.096 |
| Sodium (mmol/L) | 137.8 ± 2.63 | 137.7 ± 2.61 | 138.0 ± 2.69 | 0.874 |
| Potassium (mmol/L) | 5.73 ± 0.72 | 5.69 ± 0.74 | 5.82 ± 0.63 | 0.642 |
| Calcium (mmol/L) | 2.48 ± 0.25 | 2.49 ± 0.25 | 2.47 ± 0.25 | 0.612 |
| Phosphate (mmol/L) | 2.24 ± 0.39 | 2.21 ± 0.23 | 2.30 ± 0.29 | 0.102 |
| Ca x P product mg2/dl2 | 48.51 ± 10.62 | 46.9 ± 9.69 | 51.33 ± 9.87 | 0.024 |
CAD–coronary artery disease; MI–history of myocardial infarction; ACE/ARB—angiotensin-converting enzyme inhibitors/angiotensin receptor blockers;LVEDd–left ventricular end-diastolic diameter; LVESd–left ventricle endsystolic diameter; PWDd–posterior wall diastolic diameter; PWSd–posterior wall systolic diameter; IVSDd–interventricular septum enddiastolic diameter; IVSSd–Interventricular septum endsystolic diameter; E/e`—early transmitral flow velocity / early diastolic velocity of the mitral valve annulus;LVM–Left ventricular mass;LVMI–Left ventricular mass index; LVH–Left ventricular hypertrophy; EF–Ejection fraction; LAVI–Left atrial volume index; PTH–parathormon; CRP–C-reactive protein; NT-proBNP—N-terminal pro-hormone brain natriuretic peptide.