Fig 7. Treatment of 2D cell culture by a γ-secretase inhibitor.

2D neurons differentiated from five AD patients’ iPSC lines were treated with increasing concentrations of γ-secretase inhibitor (g-SI, 0.1, 0.5 and 1 μM; red) or DMSO as control (grey). A. Aβ40 levels in conditioned media from cells treated with γ-secretase inhibitor were significantly reduced. B. Aβ42 levels were significantly decreased in all 5 AD subjects after treatment with the γ-secretase inhibitor at all doses tested. The graph shows Mean±standard error of means (SEM); * represents p< 0.05, comparison of inhibitor vs. DMSO.