As defined in the legend, clinical isolates are shown in red while environmental isolates are blue. From the innermost ring: first black ring, L. pneumophila str. Phildadelphia-4 used as reference; second black ring, G+C content; third multicolored ring, GC skew; black bars, loci identified on the outer black bars and labeled; light blue ring 1 through 11 represent E1-P, E2-N, E3-N, E4-N, E6-N, E7-O, E8-O, E9-O, E10-P, and E11-U, respectively; red ring 1 through 11 represent C1-S, C2-S, C3-O, C4-S, C5-P, C6-S, C7-O, C8-S, C9-S, C10-S, and C11-O, respectively; outer purple ring L. pneumophila str. Paris; the outer black ring/bars highlight regions of interest, e.g., L-1 is locus 1, L-2 is locus 2, VGR-2 is variable genomic region 2, etc.