Table 4. Response of denuded vessels from healthy horses and horses with endocrinopathic laminitis (EL) to vasoconstrictors high potassium saline (KPSS), phenylephrine (PE) and 5-hydroxytryptamine (5HT).
| Denuded Laminar Arteries | Denuded Laminar Veins | Denuded Facial Skin Arteries | |||||
|---|---|---|---|---|---|---|---|
| Healthy | EL | Healthy | EL | Healthy | EL | ||
| Number | 6 | 6 | 6 | 6 | 6 | 6 | |
| KPSS | Emax mN/mm | 28.2 ± 4.1 | 26.1 ± 8.5 | 4.9 ± 1.7 | 8.8 ± 1.6* | 19.5 ± 1.4 | 17.5 ± 2.7 |
| PE | Emax mN/mm | 31.7 ± 4.8 | 22.1 ± 3.2 | 5.3 ± 0.9 | 11.3 ± 1.4* | 26.9 ± 14.4 | 21.0 ± 4.4 |
| -Log EC50 (pD2) | 6.4 ± 0.2 | 5.9 ± 0.7* | 5.4 ± 0.3 | 5.9 ± 0.4 | 6.4 ± 0.3 | 6.5 ± 0.6 | |
| 5HT | Emax mN/mm | 34.0 ± 3.8 | 23.7 ± 4.1 | 5.1 ± 1.9 | 10.4 ± 1.1* | 29.7 ± 19.7 | 10.9 ± 3.5 |
| -Log EC50 (pD2) | 6.5 ± 0.1 | 6.4 ± 0.7 | 6.4 ± 0.1 | 6.0 ± 0.3 | 7.0 ± 0.5 | 6.9 ± 0.7 | |
Responses are given as absolute values (Emax mN/mm). Sensitivity is expressed as—Log EC50 (pD2). Data are mean ± SEM. Data were compared by Student’s t-test or Mann Whitney U (healthy vs EL)
* P<0.05.