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. 2016 Sep 29;12(9):e1005088. doi: 10.1371/journal.pcbi.1005088

Table 1. Characteristics of Kidney transplant recipients and their donors.

In bold, characteristics that differ between the Cornell validation cohort and the French validation cohort (*P<0.05, two tailed t-test).

Characteristic Discovery cohort Cornell validation cohort French validation cohort
Number of Transplant Pairs with living donors 10/10 24/24 19/19
Allogenomics mismatch score AMS(SD)[range] 1335(304)[994–2033] 1094(259)[700–1630] 560(147)[349–811]
Clinical factors
Age
Donor (SD) 41 (13) 46 (10) 44(16)
Recipient (SD) 48 (10) 51 (13) 38(15)
Living Donor type
 Living related N (AMS) [SD]) 4 (1116 [143]) 13 (939 [218]) 15(503[108])*
 Living unrelated N (AMS) [SD]) 6 (1481 [300]) 11(1277 [170]) 4(769[41])*
Donor sex
 Male (%) 2 (20%) 8 (33%) 6(32%)
 Female (%) 8 (80%) 16 (67%) 13(68%)
Donor Race
 Black (%) 4(40%) 5 (21%) 2(10%)
 Non-Black (%) 6(60%) 19 (79%) 17(90%)
Recipient sex
 Male (%) 9 (90%) 13 (54%) 13 (53%)
 Female (%) 1 (10%) 11 (46%) 13 (47%)
Recipient Race
 Black (%) 4 (40%) 7 (29%) 2 (10%)
 Non-Black (%) 6 (60%) 17 (71%) 17 (90%)
Number of HLA mismatches ABDR (SD) 3.9 (1.91) 3.5 (1.89) 2.5 (1.68)*
Functional Factors
Number of Patients at 12 months 10 24 17
 Serum creatinine level at 12 months mg/dL (SD) 1.51 (0.35) 1.45 (0.41) 1.29 (0.41)
 eGFR at 12 months ml/min/1.73m2 (SD) 54.3(10) 54.3 (16.3) 61.8 (18.9)*
Number of Patients at 24 months 9 23 19
 Serum creatinine level at 24 months mg/dL (SD) 1.36 (0.19) 1.45 (0.49) 1.26 (0.3)
 eGFR at 24 months ml/min/1.73m2 (SD 59 (7.7) 54.85 (15.7) 59.3 (14.5)*
Number of Patients at 36 months 8 22 19
 Serum creatinine level at 36 months mg/dL(SD) 1.62 (0.50) 1.38 (0.40) 1.35 (0.45)
 eGFR at 36 months ml/min/1.73m2 (SD) 53.4 (15) 55.3 (15.9) 56.3 (16.4)
Number of Patients at 48 months 0 16 16
 Serum creatinine level at 48 months mg/dL(SD) - 1.34 (0.43) 1.40 (0.56)
 eGFR at 48 months ml/min/1.73m2 months (SD) - 57.4 (16.4) 55.7 (18.2)
Patients with an Acute Cellular rejection episode in the first year of transplantation, N (%) 3 (30%) 5 (20%) 2 (10%)
Immunosupression
 Calcineurin Inhibitors, n (%) 9 (90%) 24 (100%) 19 (100%)
 Corticosteroids, n (%) 0 (0%) 5 (21%) 17 (90%)*