Table 2. Single synonymous mutations changed KRAS expression, doubling times, and cell densities.
Minimum Doubling Time (hr) | KRAS Protein Expression* | Maximum Cells (x 105) | |
---|---|---|---|
WT | 44.0 | 1.0 | 7.3 |
G12V | 20.5 | 16.6 | 51.9 |
36 T->A | 28.7 | 5.4 | 15.9 |
36 T->C | 22.5 | 14.3 | 18.7 |
36 T->G | 34.2 | 3.2 | 18.8 |
39 C->A | 30.0 | 3.4 | 16.3 |
39 C->G | 28.5 | 5.8 | 16.1 |
39 C->T | 27.1 | 6.1 | 16.8 |
180 T->A | 25.1 | 4.0 | 18.1 |
180 T->C | 24.6 | 13.0 | 19.2 |
180 T->G | 28.4 | 2.4 | 21.4 |
*Normalized to WT = 1.0