Figure 2.
IBD-associated dysbiosis is recapitulated in humanized gnotobiotic mice. (A) Stool samples were obtained from patients with CD, UC, and HCs, and then inoculated into GF mice. After 2 weeks of reconstitution, stool samples from hGB mice were collected and bacterial 16S rRNA sequences were analyzed. Sample IDs of human donors correspond to those of donor-derived hGB mice. (B) Microbial community structures were analyzed by using the Yue and Clayton dissimilarity distance metric (θYC) and are shown in a nonmetric multidimensional scaling plot. (C) Shannon index (α-diversity) and number of OTUs (richness) for each group. Data are presented as means ± SD. *P < .05 by Student t test. ** P < .01.