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. 2016 Mar 3;2(4):468–481. doi: 10.1016/j.jcmgh.2016.02.003

Figure 6.

Figure 6

CD-associated microbiota promotes the development of colitis in IBD-prone mice. (A and B) Stool samples were isolated from HC-hGB mice (HC-03, HC-04, and HC-05) and CD-hGB mice (CD-01, CD-02, CD-03, CD-04, and CD-05), and then inoculated into GF WT B6 mice. After 3 weeks of reconstitution, cecal and colonic tissues were harvested. (A) Histologic score of colon. Each dot indicates an individual mouse. NS, not significant by Mann–Whitney U test. (B) A representative histologic image of WT B6-HC-hGB and CD-hGB mice. Scale bar: 200 μm. (C–E) Stool samples were isolated from HC-hGB mice and CD-hGB mice and then inoculated into GF Il10-/- mice. After 3 weeks of reconstitution, cecal and colonic tissues were harvested. (C) Colonic weights. Each dot indicates an individual mouse. **P < .01 by Mann–Whitney U test. (D) Histologic score of colon. Each dot indicates an individual mouse. **P < .01 by Mann–Whitney U test. ***P < .001. (E) A representative histologic image of colonic tissues isolated from IL10-/--HC-hGB and CD-hGB mice. Scale bar: 50 μm.