Table 1.
Normal Diet | HFD+Ad‑GFP–shRNA | HFD+Ad‑Orai1–shRNA | HFD+Vehicle | HFD+SKF96365 | |
---|---|---|---|---|---|
Body wt (g) | 30.37±0.28 | 39.63±0.62a | 38.48±0.51a | 40.01±0.66a | 39.10±0.58a |
Kidney weight (mg) | 323.5±3.1 | 398.7±5.6a | 395.2±6.8a | 402.3±11.4a | 395.6±6.3a |
Serum creatinine (mg/dl) | 0.28±0.04 | 0.53±0.07a | 0.41±0.05ab | 0.56±0.06a | 0.38±0.04ab |
UACR (mg/g) | 11.32±2.11 | 26.63±2.73a | 16.27±2.31ab | 24.12±2.93a | 16.35±2.62ab |
Values are mean±SEM, n=6–8 in each group. Statistical analyses were performed by one-way ANOVA. UACR, urine albumin-to-creatinine ratio.
P<0.05 versus mice on normal diet.
P<0.05 versus mice on HFD+Ad‑GFP–shRNA or HFD+vehicle.