Figure 1.

Population characteristics of plasma APOL1 levels in the DHS. Data on G0, G1, or G2 APOL1 (LNILNN[NY]K) or full-length APOL1 (ALDNLAR) are presented. (A) APOL1 levels as determined by the carboxy‑terminal LNI peptide or the internal ALD peptide are highly correlated. The relationship was estimated by linear regression without an intercept. (B) Plasma APOL1 levels by ethnic status in DHS. APOL1 circulates at higher levels in black participants than in other ethnic groups. WT APOL1 refers to protein as quantified by the LNILNNNYK peptide. Total APOL1 refers to protein as quantified by the internal ALD peptide. (C) G1 and G2 APOL1, as measured by the LNI peptide, circulate at levels below G0 APOL1 in either one or two risk allele carriers. (D) APOL1, as measured by the ALD peptide, is poorly correlated with overall HDL levels, but is correlated with small HDL. (E) APOL1 is more significantly correlated with plasma APOA1 compared with HDL.