Table 4.

Association between circulating APOL1 levels and CKD in nondiabetic DHS black participants

Outcome	APOL1 protein	N subjects	Model 1		Model 2
			OR (95% CI)	P Value	OR (95% CI)	P Value
CKD	Total APOL1	1479	0.95 (0.78 to 1.15)	0.58	0.99 (0.82 to 1.21)	0.96
	WT APOL1	1239	1.02 (0.81 to 1.28)	0.86	1.19 (0.87 to 1.62)	0.28
	G1 APOL1	588	1.22 (0.96 to 1.55)	0.11	1.14 (0.85 to 1.52)	0.38
	G2 APOL1	402	1.25 (0.92 to 1.70)	0.16	1.24 (0.88 to 1.75)	0.23
	G1+G2 APOL1	892	1.44 (1.19 to 1.75)	<0.001	1.17 (0.92 to 1.50)	0.2
Microalbuminuria	Total APOL1	1474	0.91 (0.74 to 1.12)	0.39	0.95 (0.77 to 1.18)	0.63
	WT APOL1	1237	1.02 (0.79 to 1.30)	0.89	1.19 (0.85 to 1.66)	0.32
	G1 APOL1	584	1.17 (0.90 to 1.52)	0.24	1.07 (0.79 to 1.47)	0.65
	G2 APOL1	400	1.08 (0.76 to 1.55)	0.66	1.06 (0.73 to 1.55)	0.75
	G1+G2 APOL1	887	1.32 (1.07 to 1.63)	<0.001	1.07 (0.82 to 1.39)	0.64
GFR<60 ml/min/1.73 m2	Total APOL1	1534	0.82 (0.58 to 1.17)	0.27	0.88 (0.62 to 1.25)	0.47
	WT APOL1	1287	0.94 (0.61 to 1.44)	0.78	0.83 (0.47 to 1.48)	0.53
	G1 APOL1	603	1.10 (0.71 to 1.72)	0.66	0.98 (0.58 to 1.63)	0.92
	G2 APOL1	415	1.61 (0.96 to 2.68)	0.07	1.80 (0.96 to 3.38)	0.07
	G1+G2 APOL1	920	1.64 (1.20 to 2.24)	0.002	1.20 (0.79 to 1.81)	0.39

The analysis includes nondiabetic DHS black participants with available data on microalbuminuria, GFR and total CKD. The analysis of allele-specific protein levels is restricted to individuals who carry at least one copy of the corresponding allele. For example, the analysis of WT APOL1 levels is confined to individuals with 0 or 1 copies of the G1 and G2 alleles. The analysis of total levels of the variant protein (G1+G2 APOL1) is restricted to individuals with at least one copy of the variant alleles (G1 or G2). Model 1 includes age, gender, and systolic BP as covariates. Model 2 is additionally adjusted for the number of copies of the risk alleles. OR are calculated per 1 SD increase in circulating APOL1 levels. N subjects, number of individuals included in each analysis. 95% CI, 95% confidence interval.