Table 5.
Association between circulating APOL1 levels and CKD in nondiabetic DHS black participants stratified by the number of APOL1 risk alleles
| Outcome | APOL1 protein | One risk allele | Two risk alleles | ||||
|---|---|---|---|---|---|---|---|
| N | OR (95% CI) | P Value | N | OR (95% CI) | P Value | ||
| CKD | Total APOL1 | 692 | 1.03 (0.77 to 1.38) | 0.83 | 199 | 0.9 (0.61 to 1.33) | 0.59 |
| WT APOL1 | 692 | 1.28 (0.84 to 1.95) | 0.25 | – | – | – | |
| G1 APOL1 | 512 | 1.19 (0.79 to 1.77) | 0.40 | 75 | 1.2 (0.78 to 1.86) | 0.41 | |
| G2 APOL1 | 370 | 1.07 (0.69 to 1.67) | 0.77 | 31 | 2.49 (0.81 to 7.66) | 0.11 | |
| G1+G2 APOL1 | 692 | 1.15 (0.75 to 1.79) | 0.52 | 199 | 1.19 (0.88 to 1.59) | 0.26 | |
| Microalbuminuria | Total APOL1 | 690 | 1.00 (0.73 to 1.37) | 0.99 | 196 | 0.8 (0.51 to 1.24) | 0.31 |
| WT APOL1 | 690 | 1.19 (0.75 to 1.90) | 0.46 | – | – | – | |
| G1 APOL1 | 509 | 1.01 (0.65 to 1.57) | 0.98 | 74 | 1.27 (0.80 to 2.01) | 0.31 | |
| G2 APOL1 | 369 | 0.84 (0.52 to 1.37) | 0.49 | 30 | 2.78 (0.64 to 12.14) | 0.17 | |
| G1+G2 APOL1 | 690 | 1.06 (0.66 to 1.69) | 0.82 | 196 | 1.09 (0.79 to 1.50) | 0.60 | |
| GFR<60 ml/min per 1.73 m2 | Total APOL1 | 715 | 1.25 (0.75 to 2.08) | 0.38 | 204 | 0.81 (0.43 to 1.52) | 0.51 |
| WT APOL1 | 715 | 1.32 (0.66 to 2.64) | 0.44 | – | – | – | |
| G1 APOL1 | 526 | 1.36 (0.70 to 2.66) | 0.37 | 76 | 0.63 (0.24 to 1.62) | 0.34 | |
| G2 APOL1 | 379 | 1.93 (0.91 to 4.11) | 0.09 | 35 | 3.99 (0.05 to 339.87) | 0.54 | |
| G1+G2 APOL1 | 715 | 1.63 (0.72 to 3.68) | 0.24 | 204 | 1.08 (0.66 to 1.77) | 0.76 | |
The analysis includes nondiabetic DHS black participants with available data on microalbuminuria, GFR and total CKD. The analysis of allele-specific protein levels is restricted to individuals who carry at least one copy of the corresponding allele. For example, the analysis of WT APOL1 levels is confined to individuals with 0 or 1 copies of the G1 and G2 alleles. The analysis of total levels of the variant protein (G1+G2 APOL1) is restricted to individuals with at least one copy of the variant alleles (G1 or G2). OR are calculated per 1 SD increase in circulating APOL1 levels. N, number of individuals included in each analysis. 95% CI, 95 % confidence interval.