Table 1.
Allelic associations for rs6677604 and different CNVs within CFHR3 and CFHR1
| Variants | Beijing Cohort, n=2067, 1185 Patients/882 Controls | Shanghai Cohort, n=1472, 722 Patients/750 Controls | Cohorts Combined, n=3539, 1907 Patients/1632 Controls | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MAF Patients/Controls | OR (95% CI) | P Value | MAF Patients/Controls | OR (95% CI) | P Value | MAF Patients/Controls | OR (95% CI) | P Value | |
| rs6677604 (A) | 0.040/0.072 | 0.55 (0.42 to 0.72) | 1.4 × 10−5 | 0.051/0.070 | 0.71 (0.52 to 0.96) | 0.02 | 0.044/0.071 | 0.61 (0.50 to 0.75) | 1.6 × 10−6 |
| CFHR3-CFHR1 | |||||||||
| Del-Del | 0.037/0.071 | 0.51 (0.38 to 0.67) | 2.3 × 10−6 | 0.046/0.069 | 0.65 (0.48 to 0.90) | 8.3 x 10−3 | 0.040/0.070 | 0.56 (0.46 to 0.70) | 8.5 × 10−8 |
| Wt-Del | 0.0076/0.0085 | 0.89 (0.45 to 1.78) | 0.74 (NS) | 0.012/0.011 | 1.10 (0.56 to 2.16) | 0.78 (NS) | 0.0094/0.0098 | 0.96 (0.59 to 1.56) | 0.87 (NS) |
| Del-Wt | 0.0025/0.0034 | 0.74 (0.24 to 2.31) | 0.61 (NS) | 0.006/0.004 | 1.57 (0.55 to 4.42) | 0.40 (NS) | 0.0039/0.0037 | 1.07 (0.50 to 2.29) | 0.86 (NS) |
| Wt-Dup | 0.0042/0.0034 | 1.24 (0.45 to 3.43) | 0.68 (NS) | 0.003/0.005 | 0.59 (0.17 to 2.03) | 0.40 (NS) | 0.0037/0.0040 | 0.92 (0.43 to 1.97) | 0.83 (NS) |
MAF, minor allele frequency; Del, deletion; Wt, wild type; Dup, duplication.