Figure 5.

Inhibition of p38 mitogen-activated protein kinase signaling enhances the anti-metastasic effect of PS VII in U2OS osteosarcoma cells. (A) U2OS cell migration was assessed by a wound healing assay following treatment with 1 μM PS VII and/or 50 μM SB203580 for 24 h. (B) U2OS cell invasion was assessed by Transwell assay following treatment with 1 μM PS VII and/or 50 μM SB203580 for 24 h. Values are presented as the mean ± standard deviation of three independent experiments. ^*P<0.05, ^**P<0.01 vs. control; ^#P<0.05, ^##P<0.01 vs. PS VII-treated cells. PS VII, Paris saponin VII.