Table II.
Characteristics of patients with chronic hepatitis B stratified by the presence of significant fibrosis and cirrhosis.
| Variable | No significant fibrosis, F=0–2 (n=24) | Significant fibrosis, F=3–6 (n=61) | P-value | No cirrhosis, F=0–4 (n=62) | Cirrhosis, F=5–6 (n=23) | P-value |
|---|---|---|---|---|---|---|
| Clinical data | ||||||
| Male | 11 (45.8%) | 41 (67.2) | 0.069 | 37 (59.7%) | 15 (65.2%) | 0.641 |
| Age (years) | 36.33±7.86 | 38.82±8.33 | 0.212 | 37.39±8.14 | 40.09±8.33 | 0.181 |
| BMI (kg/m2) | 22.46±3.83 | 22.97±2.93 | 0.513 | 22.45±3.05 | 23.83±3.43 | 0.078 |
| Biological parameters | ||||||
| AST (U/l) | 38.08±26.36 | 47.46±51.64 | 0.401 | 44.44±50.97 | 45.83±29.41 | 0.902 |
| ALT (U/l) | 49.96±37.53 | 69.89±99.92 | 0.346 | 61.11±88.36 | 72.74±85.24 | 0.588 |
| GGT (U/l) | 28.50±29.11 | 47.46±63.72 | 0.166 | 30.89±41.39 | 72.35±58.61 | 0.002 |
| Serum albumin (g/l) | 41.87±3.87 | 40.42±3.85 | 0.123 | 41.48±3.71 | 39.08±3.92 | 0.011 |
| Total bilirubin (µmol/l) | 11.35±4.84 | 16.17±14.62 | 0.356 | 12.43±5.58 | 20.78±18.46 | 0.108 |
| WBC (×1,000/mm3) | 6.24±1.51 | 5.73±1.61 | 0.189 | 5.95±1.50 | 5.69±1.84 | 0.506 |
| Platelet count (×1,000/mm3) | 196.25±37.01 | 180.07±69.00 | 0.280 | 196.71±61.85 | 152.09±45.00 | 0.003 |
| Fasting glucose (mmol/l) | 5.20±1.09 | 5.52±1.52 | 0.354 | 5.39±1.17 | 5.52±1.96 | 0.713 |
| HBV-DNA (log10 IU/l) | 6.34±2.19 | 6.07±1.81 | 0.560 | 6.16±1.99 | 6.11±1.74 | 0.917 |
| HBeAg positive | 13 (54.2%) | 34 (55.7%) | 0.102 | 36 (58.1%) | 12 (52.2%) | 0.627 |
| Ultrasonographic parameters | ||||||
| Portal vein diameter (mm) | 10.87±1.70 | 11.58±1.47 | 0.061 | 11.16±1.65 | 11.95±1.16 | 0.039 |
| Portal vein velocity (cm/s) | 22.80±5.36 | 21.40±7.02 | 0.380 | 22.32±6.29 | 20.37±7.29 | 0.227 |
| Hepatic artery diameter (mm) | 3.24±0.45 | 3.42±0.62 | 0.008 | 3.35±0.52 | 3.65±0.61 | 0.004 |
| Hepatic artery velocity (cm/s) | 67.81±25.41 | 73.22±67.81 | 0.328 | 70.76±24.11 | 74.21±19.17 | 0.539 |
| Hepatic artery resistive index | 0.73±0.052 | 0.75±0.082 | 0.519 | 0.75±0.053 | 0.72±0.11 | 0.125 |
| Spleen thickness (mm) | 31.27±4.80 | 33.52±6.17 | 0.069 | 32.19±4.96 | 34.57±5.25 | 0.038 |
| Spleen diameter (mm) | 89.50±6.80 | 93.98±10.38 | 0.054 | 90.57±7.68 | 98.50±12.09 | 0.001 |
| Splenic index | 30.15±7.03 | 36.53±9.76 | 0.005 | 31.51±7.25 | 43.39±9.49 | <0.001 |
| Splenoportal index | 1.21±0.27 | 2.02±0.87 | <0.001 | 1.51±0.66 | 2.54±0.80 | <0.001 |
| Splenic artery diameter (mm) | 4.10±0.71 | 4.43±0.86 | 0.092 | 4.20±0.76 | 4.71±0.92 | 0.012 |
| Splenic artery velocity (cm/s) | 73.48±19.37 | 73.75±22.37 | 0.958 | 73.36±21.31 | 74.55±22.30 | 0.822 |
| Splenic artery resistive index | 0.60±0.070 | 1.93±1.16 | 0.527 | 1.89±0.083 | 0.64±0.075 | 0.555 |
| Splenic vein diameter (mm) | 5.97±1.08 | 6.17±1.23 | 0.496 | 5.89±1.08 | 6.71±1.29 | 0.004 |
| Splenic vein velocity (cm/s) | 19.28±8.47 | 16.91±5.46 | 0.130 | 18.50±6.76 | 15.11±5.00 | 0.031 |
| APRI | 21.91±21.71 | 29.60±7.17 | 0.247 | 24.85±27.65 | 34.37±26.11 | 0.156 |
| FIB-4 | 1.08±0.67 | 1.62±1.03 | 0.019 | 1.27±0.85 | 2.00±1.09 | 0.002 |
| Liver stiffness (FibroScan, kPa) | 6.84±2.46 | 10.00±7.17 | 0.039 | 7.20±2.72 | 14.25±9.80 | <0.001 |
| LFI | 1.83±0.33 | 2.26±0.49 | <0.001 | 2.00±0.42 | 2.52±0.46 | <0.001 |
Results are expressed as the mean ± standard deviation or number of patients (%). ALT, alanine aminotransferase; AST, aspartate aminotransferase; APRI, aspartate aminotransferase to platelet ratio index; BMI, body mass index; FIB-4, fibrosis-4 index; GGT, γ-glutamyl transferase; HBV, hepatitis B virus; LFI, liver fibrosis index; WBC, white blood cell; HbeAg, hepatitis B virus envelope antigen.