Skip to main content
. 2016 Aug 26;14(4):3609–3619. doi: 10.3892/mmr.2016.5682

Table IV.

Analysis of variables associated with the presence of cirrhosis in patients with chronic hepatitis B.

Variable Univariate analysis
Multivariate analysis
OR 95% CI P-value OR 95% CI P-value
Clinical data
 Male (%)   1.267 0.468–3.433   0.642
 Age (years)   1.042 0.981–1.108   0.181
 BMI (kg/m2)   1.143 0.981–1.331   0.086
Biological parameters
 AST (U/l)   1.001 0.991–1.011   0.901
 ALT (U/l)   1.001 0.996–1.006   0.590
 GGT (U/l)   1.014 1.002–1.026   0.018   1.012 1.000–1.024 0.049
 Serum albumin (g/l)   0.849 0.744–0.969   0.015   1.306 0.986–1.729 0.063
 Total bilirubin (µmol/l)   1.024 0.975–1.076   0.341
 WBC (×1,000/mm3)   0.898 0.656–1.229   0.502
 Platelet count (×1,000/mm3)   0.982 0.970–0.993   0.002   0.989 0.966–1.012 0.343
 Fasting glucose (mmol/l)   1.064 0.767–1.475   0.710
HBV-DNA (log10 IU/l)   0.987 0.768–1.268   0.916
HBeAg positive (%)   0.842 0.322–2.198   0.725
Ultrasonographic parameters
 Portal vein diameter (mm)   1.418 1.010–1.992   0.044   0.835 0.447–1.559 0.571
 Portal vein velocity (cm/s)   0.954 0.883–1.030   0.226
 Hepatic artery diameter (mm)   2.133 1.539–4.589   0.002   4.467 0.621–32.149 0.137
 Hepatic artery velocity (cm/s)   1.007 0.986–1.028   0.543
 Hepatic artery resistive index   0.008 0.001–6.408   0.158
 Spleen thickness (mm)   1.102 1.002–1.213   0.045   0.977 0.720–1.328 0.884
 Spleen diameter (mm)   1.101 1.032–1.176   0.004   1.155 0.969–1.377 0.107
 Splenic index   1.188 1.094–1.290 <0.001   1.100 0.937–1.292 0.245
 Splenoportal index   6.513 2.583–16.422 <0.001   5.676 1.939–16.618 0.002
 Splenic artery diameter (mm)   2.103 1.141–3.874   0.017   0.483 0.068–3.437 0.468
 Splenic artery velocity (cm/s)   1.003 0.981–1.025   0.820
 Splenic artery resistive index   0.950 0.699–1.291   0.744
 Splenic vein diameter (mm)   1.890 1.199–2.980   0.006   2.729 0.701–10.622 0.148
 Splenic vein velocity (cm/s)   0.896 0.809–0.992   0.034   1.039 0.974–1.323 0.103
APRI   1.011 0.995–1.029   0.186
FIB-4   2.082 1.254–3.456   0.005
Liver stiffness (FibroScan kPa)   1.492 1.247–1.785 <0.001
LFI 13.944 3.603–53.960 <0.001 14.102 2.873–69.221 0.001

ALT, alanine aminotransferase; AST, aspartate aminotransferase; APRI, aspartate aminotransferase to platelet ratio index; BMI, body mass index; FIB-4, fibrosis-4 index; GGT, γ-glutamyl transferase; HBV, hepatitis B virus; LFI, liver-fibrosis index; WBC, white blood cell; HbeAg, hepatitis B virus envelope antigen.